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    Annoroad Gene Technology Co Ltd stereo seq library construction
    High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics <t>(Stereo-seq).</t> F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment
    Stereo Seq Library Construction, supplied by Annoroad Gene Technology Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    stereo seq library construction - by Bioz Stars, 2026-05
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    1) Product Images from "High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α–astrocyte–SLC1A2 pathway"

    Article Title: High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α–astrocyte–SLC1A2 pathway

    Journal: Journal of Neuroinflammation

    doi: 10.1186/s12974-026-03744-z

    High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics (Stereo-seq). F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment
    Figure Legend Snippet: High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics (Stereo-seq). F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment

    Techniques Used: Control, Selection, Staining, RNA Sequencing, Spatial Transcriptomics, Marker, Comparison



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    High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics <t>(Stereo-seq).</t> F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment
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    High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics (Stereo-seq). F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment

    Journal: Journal of Neuroinflammation

    Article Title: High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α–astrocyte–SLC1A2 pathway

    doi: 10.1186/s12974-026-03744-z

    Figure Lengend Snippet: High-altitude hypoxia induces cognitive impairment and hippocampal cellular remodeling in humans and mice. A Schematic overview of the human cohort design and grouping, illustrating low-altitude control participants and cohorts with different durations of high-altitude residence and follow-up time points. B Cognitive performance across cohorts with increasing high-altitude residence duration, including Montreal Cognitive Assessment (MoCA) scores and between-group comparisons of accuracy and reaction time in computerized tasks (GO/No-Go, N-back, and Object Selection). Sample sizes and statistical methods are described in the Methods. C Representative hematoxylin and eosin (HE)–stained hippocampal sections from control (CON), 3-day (H3D), and 28-day (H28D) high-altitude–exposed mice, showing hypoxia-associated neuronal injury. D Behavioral assessment in mice. Left, discrimination ratio (DR) in the Novel Object Recognition (NOR) test; right, time spent and distance traveled in the target quadrant during the Morris Water Maze (MWM) probe trial ( n = 5 per group). E Workflow of sample collection and analysis for hippocampal single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics (Stereo-seq). F UMAP visualization of integrated snRNA-seq data showing major hippocampal cell types. G Heatmap of representative marker genes used for cell-type annotation and comparison. H HALLMARK_HYPOXIA gene set scores across major cell types. I Gene Ontology (GO) enrichment analysis of cell-type–specific differentially expressed genes, highlighting processes related to neurotransmitter regulation, lysosomal function, and vascular signaling. Data are presented as mean ± SEM. Statistical analyses were performed using one-way analysis of variance (one-way ANOVA) followed by Tukey’s honestly significant difference (HSD) post hoc test. * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: CON, low-altitude control; H3D, high-altitude 3-day model; H28D, high-altitude 28-day model; MoCA, Montreal Cognitive Assessment

    Article Snippet: Stereo-seq library construction was carried out by Annoroad Gene Technology.

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